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Abstract
The influence of linoleic acid upon the sedimentation of washed erythrocytes from
multiple sclerosis patients and controls was investigated in the present study. Linoleic
acid, especially in the concentration of 250 μM and 500 μM, caused slowing of erythrocyte
sedimentation and this effect was significantly greater in multiple sclerosis than
in controls. These findings with all probability reflect an unsaturated fatty acid-dependent
membrane alteration in multiple sclerosis and are analogous to results obtained earlier
by several authors by using cytopherometric measurements.
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References
- Fatty acid composition of phospholipids from platelets and erythrocytes in multiple sclerosis.J. Neurol. Neurosurg. Psychiat. 1970; 33: 506-510
- Levels of linoleate and arachidonate in red blood cells of healthy individuals and patients with multiple sclerosis.J. Neurol. Neurosurg, Psychiat. 1980; 43: 106-110
- Red blood cell and adipose tissue fatty acids in mild inactive multiple sclerosis.Acta Neurol. Scand. 1990; 82: 43-50
- Erythrocyte-UFA (Eufa) mobility tests for multiple sclerosis: Implication for pathogenesis and handling of the disease.J. Neurol. 1977; 214: 113-127
- E-UFA test in multiple sclerosis.Boll. Ist. Sieroter, Milan. 1977; 56: 583-588
- Simplified red-cell electrophoretic mobility test for multiple sclerosis.Lancet. 1979; i: 1138-1139
- Erythrocyte electrophoretic mobility test for multiple sclerosis.Lancet. 1979; i: 165-166
Article info
Publication history
Accepted:
July 3,
1991
Received:
May 2,
1991
Identification
Copyright
© 1991 Published by Elsevier Inc.
