Advertisement
Review| Volume 44, ISSUE 3, P135-147, November 1991

The role of platelet activating factor (PAF) in the pathogenesis of gastric ulcers

DOI:https://doi.org/10.1016/0952-3278(91)90048-A
The role of platelet activating factor (PAF) in the pathogenesis of gastric ulcers
Next ArticleEffects of diltiazem on thromboxane B2 production from platelet-rich plasma and whole blood
      This paper is only available as a PDF. To read, Please Download here.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Prostaglandins, Leukotrienes and Essential Fatty Acids
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Benveniste J
        • Henson PM
        • Cochrane CG
        Leukocyte-dependent histamine release from rabbit platelets: The role of IgE, basophils and a platelet-activating factor.
        J Exp Med. 1972; 136: 1356-1377
        • Pinckard RN
        • Farr RS
        • Hanahan DJ
        Physicochemical and functional identity of platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils.
        J Immunol. 1979; 123: 1847-1857
        • Hanahan DJ
        Platelet activating factor: A biologically active phosphoglyceride.
        Ann Rev Biochem. 1986; 55: 483-509
        • Braquet P
        • Touqui L
        • Shen TY
        • et al.
        Perspectives in platelet-activating factor research.
        Pharmacol Rev. 1987; 39: 97-145
      5. Snyder F Platelet-activating factor and related lipids mediators. Plenum Press, New York1987
        • Pinckard RN
        • Ludwig JC
        • McManus LM
        Platelet-activating factors.
        in: Gallin JI Goldstein IM Snyderman R Inflammation: Basic Principles and Clinical Correlates. Raven Press, New York1988: 139-167
      7. Saito K Hanahan DJ Platelet-activating factor and diseases. International Medical Publishers, Tokyo1989
        • Söling H-D
        • Fest W
        Synthesis of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in exocrine glands and its control by secretagogues.
        J Biol Chem. 1986; 261: 13916-13922
        • Bussolino F
        • Gremo F
        • Tetta C
        • et al.
        Production of platelet-activating factor by chick retina.
        J Biol Chem. 1986; 261: 16502-16508
        • Kumar R
        • Harvey SAK
        • Kester M
        • et al.
        Production and effects of platelet-activating factor in the rat brain.
        Biochim Biophys Acta. 1988; 963: 375-383
        • Tokumura A
        • Kamiyasu K
        • Takauchi K
        • et al.
        Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain.
        Biochem Biophys Res Commun. 1987; 145: 415-425
        • Hoffman DR
        • Truong CT
        • Johnston JM
        Metabolism and function of platelet-activating factor in fetal rabbit lung development.
        Biochim Biophys Acta. 1986; 879: 88-96
        • Salem P
        • Denizot Y
        • Pitton C
        • et al.
        Presence of paf-acether in human thymus.
        FEBS Lett. 1989; 257: 49-51
        • Sugatani J
        • Fujimura K
        • Miwa M
        • et al.
        Occurrence of platelet-activating factor (PAF) in normal rat stomach and alteration of PAF level by water immersion stress.
        FASEB J. 1989; 3: 65-70
        • Yasuda K
        • Satouchi K
        • Saito K
        Platelet-activating factor in normal rat uterus.
        Biochem Biophys Res Commun. 1986; 138: 1231-1236
        • Billah MM
        • Renzo GCD
        • Ban C
        • et al.
        Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor.
        Prostaglandins. 1985; 30: 841-850
        • Saito K
        • Nakayama R
        • Yasuda K
        • et al.
        PAF analogues in normal rat tissues.
        in: Burlingame AL McCloskey JA Biological Mass Spectrometry. Elsevier, Amsterdam1990: 527-547
        • Rosam A-C
        • Wallace JL
        • Whittle BJR
        Potent ulcerogenic actions of platelet-activating factor on the stomach.
        Nature. 1986; 319: 54-56
        • Snyder F
        Biochemistry of platelet-activating factor: A unique class of biologically active phospholipids.
        in: 3rd Ed. Proc Soc Exp Biol Med. 190. 1989: 125-135
        • Prescott SM
        • Zimmerman GA
        • McIntyre TM
        Platelet-activating factor.
        J Biol Chem. 1990; 265: 17381-17384
        • Billah MM
        • Eckel Myers RF
        • et al.
        Metabolism of platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human promyelocytic leukemic HL60 cells. Simulated expression of phospholipase A2 and acetyltransferase requires differentiation.
        J Biol Chem. 1986; 261: 5824-5831
        • Wykle RL
        • Malone B
        • Snyder F
        Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and plateletaggregating lipid.
        J Biol Chem. 1980; 255: 10256-10260
        • Lenihan DJ
        • Lee T-C
        Regulation of platelet activating factor synthesis: Modulation of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine: acetyl-CoA acetyltransferase by phosphorylation and dephosphorylation in rat spleen microsomes.
        Biochem Biophys Res Commun. 1984; 120: 834-839
        • Domenech C
        • Domenech EM-D
        • Söling H-D
        Regulation of acetyl-CoA: 1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase (lyso-PAF-acetyltransferase) in exocrine glands. Evidence for an activation via phosphorylation by calcium/calmodulin-dependent protein kinase.
        J Biol Chem. 1987; 262: 5671-5676
        • Nieto ML
        • Velasco S
        • Sanchez-Crespo M
        Modulation of acetyl-CoA: 1-alkyl-2-lyso-sn-glycero-3-phosphocholine (lysoPAF) acetyltransferase in human polymorphonuclears. The role of cyclic AMP-dependent and phospholipid sensitive, calcium-dependent protein kinases.
        J Biol Chem. 1988; 263: 4607-4611
        • Ramesha CS
        • Pickett WC
        Platelet-activating factor and leukotriene biosynthesis is inhibited in polymorphonuclear leukocytes depleted of arachidonic acid.
        J Biol Chem. 1986; 261: 7592-7595
        • Billah MM
        • Bryant RW
        • Siegel MI
        Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2.
        J Biol Chem. 1985; 260: 6899-6906
        • Peplow PV
        • Mikhailidis DP
        Platelet-activating factor (PAF) and its relation to prostaglandins, leukotrienes and other aspects of arachidonate metabolism.
        Prostagl Leukotr Essentl Fatty Acids. 1990; 41: 71-82
        • Camussi G
        • Bussolino F
        • Salvidio G
        • et al.
        Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor.
        J Exp Med. 1987; 166: 1390-1404
        • Sisson JH
        • Prescott SM
        • McIntyre TM
        • et al.
        Production of Platelet-activating factor by stimulated human polymorphonuclear leukocytes. Correlation of synthesis with release, functional events, and leukotriene B4 metabolism.
        J Immunol. 1987; 138: 3918-3926
        • Tessner TG
        • O'Flaherty JT
        • Wykle RL
        Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites.
        J Biol Chem. 1989; 264: 4794-4799
        • Prescott SM
        • Zimmerman GA
        • McIntyre TM
        Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine when stimulated with thrombin.
        in: 3rd Ed. Proc Natl Acad Sci USA. 81. 1984: 3534-3538
        • McIntyre TM
        • Zimmerman GA
        • Satoh K
        • et al.
        Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate.
        J Clin Invest. 1985; 76: 271-280
        • McIntyre TM
        • Zimmerman GA
        • Prescott SM
        Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils.
        in: 3rd Ed. Proc Natl Acad Sci USA. 83. 1986: 2204-2208
        • Bussolino F
        • Camussi G
        • Baglioni C
        Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin 1α.
        J Biol Chem. 1988; 263: 11856-11861
        • Lewis MS
        • Whatley RE
        • Cain P
        • et al.
        Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion.
        J Clin Invest. 1988; 82: 2045-2055
        • Whatley RE
        • Zimmerman GA
        • McIntyre TM
        • et al.
        Endothelium from diverse vascular sources synthesizes platelet-activating factor.
        Arteriosclerosis. 1988; 8: 321-331
        • Whatley RE
        • Nelson P
        • Zimmerman GA
        • et al.
        The regulation of platelet-activating factor production in endothelial cells. The role of calcium and protein kinase C.
        J Biol Chem. 1989; 264: 6325-6333
        • Albert DH
        • Snyder F
        Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine by rat alveolar macrophages. Phospholipase A2 and acetyltransferase activities during phagocytosis and ionophore stimulation.
        J Biol Chem. 1983; 258: 97-102
        • Renooij W
        • Snyder F
        Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues.
        Biochim Biophys Acta. 1981; 663: 545-556
        • Francescangeli E
        • Goracci G
        The de novo biosynthesis of platelet-activating factor in rat brain.
        Biochem Biophys Res Commun. 1989; 161: 107-112
        • Hoffman DR
        • Bateman MK
        • Johnston JM
        Synthesis of platelet activating factor by cholinephosphotransferase in developing fetal rabbit lung.
        Lipids. 1988; 23: 96-100
        • Fernandez-Gallardo S
        • Gijon MA
        • Garcia MC
        • et al.
        Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the ‘de novo’ pathway and modulation by fatty acids.
        Biochem J. 1988; 254: 707-714
        • Farr RS
        • Wardlow ML
        • Cox CP
        • et al.
        Human serum acid-labile factor in an acylhydrolase that inactivates platelet-activating factor.
        in: 3rd Ed. Fed Proc. 42. 1983: 3120-3122
        • Yanoshita R
        • Kudo I
        • Ikizawa K
        • et al.
        Hydrolysis of platelet activating factor and its methylated analogs by acetylhydrolase.
        J Biochem. 1988; 103: 815-819
        • Blank ML
        • Lee T-C
        • Fitzgerald V
        • et al.
        A specific acetylhydrolase for 1-alkyl-2-actyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid).
        J Biol Chem. 1981; 256: 175-178
        • Pritchard PH
        • Chonn A
        • Yeung CCH
        The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease).
        Blood. 1985; 66: 1476-1478
        • Miwa M
        • Miyake T
        • Yamanaka T
        • et al.
        Characterization of serum platelet-activating factor (PAF) acetylhydrolase: Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children.
        J Clin Invest. 1988; 82: 1983-1991
        • Satoh K
        • Imaizumi T
        • Kawamura Y
        • et al.
        Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from patients with ischemic cerebrovascular disease.
        Prostaglandins. 1988; 35: 685-698
        • Fujimura K
        • Sugatani J
        • Miwa M
        • et al.
        Serum platelet-activating factor acetylhydrolase activity in rats with gastric ulcers induced by water-immersion stress.
        Scand J Gastroenterol. 1989; 24: 59-62
        • Sugiura T
        • Masuzawa Y
        • Nakagawa Y
        • et al.
        Transacylation of lyso-platelet-activating factor and other lysophospholipids by macrophage microsomes.
        J Biol Chem. 1987; 262: 1199-1205
        • Kramer RM
        • Patton GM
        • Pritzker CR
        • et al.
        Metabolism of platelet-activating factor in human platelets. Transacylase-mediated synthesis of 1-0-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine.
        J Biol Chem. 1984; 259: 13316-13320
        • Robinson M
        • Blank ML
        • Snyder F
        Acylation of lysophospholipids by rabbit alveolar macrophages: Specificities of CoA-dependent, and CoA-independent reactions.
        J Biol Chem. 1985; 260: 7889-7895
        • Sugiura T
        • Waku K
        CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-0-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes.
        Biochem Biophys Res Commun. 1985; 127: 384-390
        • Chilton FH
        • O'Flaherty JT
        • Ellis JM
        • et al.
        Selective acylation of lyso platelet activating factor by arachidonate in human neutrophils.
        J Biol Chem. 1983; 258: 7268-7271
        • Honda Z
        • Nakamura M
        • Miki I
        • et al.
        Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung.
        Nature. 1991; 349: 342-346
        • Hwang S-B
        Specific receptors of platelet-activating factor, receptor heterogeneity, and signal transduction mechanisms.
        J Lipid Mediat. 1990; 2: 123-158
        • Lapetina EG
        Platelet-activating factor stimulates the phosphatidylinositol cycle. Appearance of phosphatidic acid is associated with the release of serotonin in horse platelets.
        J Biol Chem. 1982; 257: 7314-7317
        • MacIntyre DE
        • Pollock WK
        Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets.
        Biochem J. 1983; 212: 433-437
        • Shukla SD
        • Buxton DB
        • Olson MS
        • et al.
        Acetylglycerol ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis.
        J Biol Chem. 1983; 258: 10212-10214
        • Verghese MW
        • Charles L
        • Jakoi L
        • et al.
        Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants.
        J Immunol. 1987; 138: 4374-4380
        • Avdonin PV
        • Cheglakov IB
        • Boogry EM
        • et al.
        Evidence for the receptor-operated calcium channels in human platelet plasma membrane.
        Thromb Res. 1987; 46: 29-37
        • Naccache PH
        • Molski MM
        • Volpi M
        • et al.
        Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertusis toxin and phorbol ester.
        Biochem Biophys Res Commun. 1985; 130: 677-684
        • Kornecki E
        • Ehrlich YH
        Neuroregulatory and neuropathological actions of the ether-phospholipid platelet-activating factor.
        Science. 1988; 240: 1792-1794
        • Ng DS
        • Wong K
        Effect of platelet-activating factor (PAF) on cytosolic free calcium in human peripheral blood mononuclear leukocytes.
        Res Commun Chem Pathol Pharmacol. 1989; 64: 351-354
        • Sage SO
        • Rink TJ
        The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets.
        J Biol Chem. 1987; 262: 16364-16369
        • Pinckard RN
        Platelet-activating factor (PAF): Molecular heterogeneity and (patho)biology.
        in: Saito K Hanahan DJ Platelet-activating factor and diseases. International Medical Publishers, Tokyo1989: 37-50
        • Nakayama R
        • Yasuda K
        • Satouchi K
        • et al.
        1-0-Hexadec-1′-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity.
        Biochem Biophys Res Commun. 1988; 151: 1256-1261
        • Satouchi K
        • Oda M
        • Yasunaga K
        • et al.
        Evidence for production of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine concomitantly with platelet-activating factor.
        Biochem Biophys Res Commun. 1985; 128: 1409-1417
        • Tessner TG
        • Wykle RL
        Stimulated neutrophils produce an ethanolamine plasmalogen analog of platelet activating factor.
        J Biol Chem. 1987; 262: 12660-12664
        • Sugatani J
        • Lee DY
        • Hughes KT
        • et al.
        Development of a novel scintillation proximity radioimmunoassay for platelet-activating factor measurement: Comparison with bioassay and Math Eq techniques.
        Life Sci. 1990; 46: 1443-1450
        • Satouchi K
        • Pinckard RN
        • McManus LM
        • et al.
        Modification of the polar head group of acetyl glyceryl ether phosphorylcholine and subsequent effects upon platelet activation.
        J Biol Chem. 1981; 256: 4425-4432
        • Wallace JL
        • Whittle BJR
        Profile of gastrointestinal damage induced by platelet-activating factor.
        Prostaglandins. 1986; 32: 137-141
        • Blank ML
        • Cress EA
        • Whittle T
        • et al.
        In vivo metabolism of a new class of biologically active phospholipids: 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet activating-hypotensive phospholipid.
        Life Sci. 1981; 29: 769-775
        • Esplugues JV
        • Whittle BJR
        Gastric mucosal damage induced by local intra-arterial administration of Paf in the rat.
        Br J Pharmacol. 1988; 93: 222-228
        • Whittle BJR
        • Kauffman GL
        • Wallace JL
        Gastric vascular and mucosal damaging actions of platelet activating factor in the canine stomach.
        in: 3rd Ed. Advances in Prostaglandin, Thromboxane and Leukotriene Research. Vol 17. Raven Press, New York1987: 285-292
        • Wallace JL
        • Whittle BJR
        Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants.
        Prostaglandins. 1986; 31: 989-998
        • Levy JV
        Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip.
        Biochem Biophys Res Commun. 1987; 146: 855-860
        • Esplugues JV
        • Whittle BJR
        Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats.
        Am J Physiol. 1989; 256: G275-G282
        • Wallace JL
        • Whittle BJR
        Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration.
        Br J Pharmacol. 1986; 89: 415-422
        • Konturek SJ
        • Brzozowski T
        • Drozdowicz D
        • et al.
        Role of leukotrienes and platelet activating factor in acute gastric mucosal lesions in rats.
        Eur J Pharmacol. 1989; 164: 285-292
        • Etienne A
        • Thonier F
        • Hecquet F
        • et al.
        Role of neutrophils in gastric damage induced by platelet activating factor.
        Naunyn-Schmiedeberg's Arch Pharmacol. 1988; 338: 422-425
        • Yoshikawa T
        • Naito Y
        • Ueda S
        • et al.
        Role of oxygen-derived free radicals in the pathogenesis of gastric mucosal lesions in rats.
        J Clin Gastroenterol. 1990; 12: S65-S71
        • Watanabe K
        • Yano S
        • Kojima T
        • et al.
        Formation of gastric mucosal lesions by platelet activating factor (PAF): Comparison of the effects of drugs on gastric lesions induced by hypovolumic shock and by PAF.
        in: Ogura Y Kisara K Trends in pharmacological research on platelet activating factor (PAF) in Japan. Ishiyaku Euro-America, Tokyo1988: 170-181
        • Steel G
        • Wallace JL
        • Whittle BJR
        Failure of prostaglandin E2 and its 16, 16-dimethyl analogue to prevent the gastric mucosal damage induced by Paf..
        Br J Pharmacol. 1987; 90: 365-371
        • Esplugues JV
        • Whittle BJR
        • Moncada S
        Local opioid-sensitive afferent sensory neurones in the modulation of gastric damage induced 9 by Paf.
        Br J Pharmacol. 1989; 97: 579-585
        • Wallace JL
        • MacNaughton WK
        Gastrointestinal damage induced by platelet-activating factor: role of leukotrienes.
        Eur J Pharmacol. 1988; 151: 43-50
        • Sun DCH
        Etiology and pathology of peptic ulcer.
        in: 3rd Ed. Gastroenterology. Vol 1. Saunders, Philadelphia1974: 579-610
        • Braquet P
        • Etienne A
        • Mencia-Huerta J-M
        • et al.
        Effects of the specific platelet-activating factor antagonists, BN 52021 and BN 52063, on various experimental gastrointestinal ulcerations.
        Eur J Pharmacol. 1988; 150: 269-276
        • Soybel DI
        • Ashley SW
        • Cheung LY
        Effects of platelet-activating factor on canine gastric mucosal blood flow and permeability to luminal acid.
        Am J Surg. 1988; 155: 180-185
        • Nogami M
        • Suko M
        • Miyamoto T
        The effect of platelet-activating factor on [14C]aminopyrine uptake by isolated guinea pig parietal cells.
        Biochem Biophys Res Commun. 1990; 168: 1047-1052
        • Gay JC
        • Beckman JK
        • Zaboy KA
        • et al.
        Modulation of neutrophil oxidative responses to soluble stimuli by platelet-activating factor.
        Blood. 1986; 67: 931-936
        • Whittle BJR
        • Morishita T
        • Ohya Y
        • et al.
        Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa.
        Am J Physiol. 1986; 251: G772-G778
        • Binnaka T
        • Yamaguchi T
        • Hirohara J
        • et al.
        Gastric mucosal damage induced in rats by intravenous administration of platelet-activating factor.
        Scand J Gastroenterol. 1989; 24: 67-70
        • Binnaka T
        • Yamaguchi T
        • Kubota Y
        • et al.
        Gastric hemodynamic disturbance induced by hemorrhagic shock in rats. Role of platelet-activating factor.
        Scand J Gastroenterol. 1990; 25: 555-562
        • Dembinska-Kiec A
        • Peskar BA
        • Muller MK
        • et al.
        The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed.
        Prostaglandins. 1989; 37: 69-91
        • Chu K-M
        • Gerber JG
        • Nies AS
        Local vasodilator effect of platelet activating factor in the gastric, mesenteric and femoral arteries of the dog.
        J Pharmacol Exp Ther. 1988; 246: 996-1000
        • Wallace JL
        • Steel G
        • Whittle BJR
        • et al.
        Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists.
        Gastroenterology. 1987; 93: 765-773
        • Henson PM
        • Gould D
        • Becker EL
        Activation of stimulus-specific serine esterases (proteases) in the initiation of platelet secretion. I Demonstration with organophosphorus inhibitors.
        J Exp Med. 1976; 144: 1657-1673
        • Shaw JO
        • Pinckard RN
        • Ferrigni KS
        • et al.
        Activation of human neutrophils with 1-0-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor).
        J Immunol. 1981; 127: 1250-1255
        • Grigorian GY
        • Ryan US
        Platelet-activating factor effects on bovine pulmonary artery endothelial cells.
        Cir Res. 1987; 61: 389-395
        • Bussolino F
        • Camussi G
        • Aglietta M
        • et al.
        Human endothelial cells are target for platelet-activating factor. I. Platelet-activating factor induces changes in cytoskeleton structures.
        J Immunol. 1987; 139: 2439-2446
        • Hellewell PG
        • Williams TJ
        A specific antagonist of platelet-activating factor suppresses oedema formation in an arthus reaction but not oedema induced by leukocyte chemoattractants in rabbit skin.
        J Immunol. 1986; 137: 302-307
        • Hwang S-B
        • Lam M-H
        • Li C-L
        • et al.
        Release of platelet activating factor and its involvement in the first phase of carrageenin-induced rat foot edema.
        Eur J Pharmacol. 1986; 120: 33-41
        • Suematsu M
        • Kurose I
        • Asako H
        • et al.
        In vivo visualization of oxyradical-dependent photoemission during endothelium-granulocyte interaction in microvascular beds treated with platelet-activating factor.
        J Biochem. 1989; 106: 355-360
        • Kubes P
        • Suzuki M
        • Granger DN
        Platelet-activating factor-induced microvascular dysfunction: role of adherent leukocytes.
        Am J Physiol. 1990; 258: G158-G163
        • Brambilla A
        • Ghiorzi A
        • Giachetti A
        WEB 2086 a potent PAF antagonist exerts protective effect toward PAF-induced gastric damage.
        Pharm Res Commun. 1987; 19: 147-151
        • Robert A
        • Nezamis JE
        • Lancaster C
        • et al.
        Cytoprotection by prostaglangins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.
        Gastroenterology. 1979; 77: 433-443
        • Pique JM
        • Esplugues JV
        • Whittle BJR
        Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF.
        Am J Physiol. 1990; 258: G352-G357
        • Ibbotson GC
        • Wallace JL
        Beneficial effects of prostaglandin E2 in endotoxic shock are unrelated to effects on PAF-acether synthesis.
        Prostaglandins. 1989; 37: 237-250

      111. Sugatani J, Fujimura K, Miwa M et al. Molecular heterogeneity of platelet-activating factor (PAF) in normal rat glandular stomach determined by gas chromatography/mass spectrometry: alteration in molecular species of PAF by water-immersion stress. Lipids, in press

        • Doebber TW
        • Wu MS
        • Robbins JC
        • et al.
        Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone.
        Biochem Biophys Res Commun. 1985; 127: 799-808
        • Terashita Z
        • Imura Y
        • Nishikawa K
        • et al.
        Is platelet activating factor (PAF) a mediator of edotoxin shock?.
        Eur J Pharmacol. 1985; 109: 257-261
        • Lagente V
        • Fortes ZB
        • Garcia-Leme J
        • et al.
        PAF-acether and endotoxin display similar effects on rat mesenteric microvessels: Inhibition by specific antagonists.
        J Pharmacol Exp Ther. 1988; 247: 254-261
        • Chang S-W
        • Feddersen C-O
        • Henson PM
        • et al.
        Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats.
        J Clin Invest. 1987; 79: 1498-1509
        • Diez FL
        • Nieto ML
        • Fernandez-Gallardo S
        • et al.
        Occupancy of platelet receptors for platelet-activating factor in patients with septicemia.
        J Clin Invest. 1989; 83: 1733-1740
        • Wallace JL
        • Steel G
        • Whittle BJR
        Gastrointestinal plasma leakage in endotoxic shock. Inhibition by prostaglandin E2 and by a platelet-activating factor antagonist.
        Can J Physiol Pharmacol. 1987; 65: 1428-1432
        • Remick DG
        • Strieter RM
        • Eskandari MK
        • et al.
        Role of tumor necrosis factor-α in lipopolysaccharide-induced pathologic alterations.
        Am J Pathol. 1990; 136: 49-60
        • Rabinovici R
        • Yue T-L
        • Farhat M
        • et al.
        Platelet activating factor (PAF) and tumor necrosis factor-α (TNFα) interactions in endotoxemic shock: Studies with BN 50739, a novel PAF antagonist.
        J Pharmacol Exp Ther. 1990; 255: 256-263
        • Valone FH
        • Epstein LB
        Biphasic platelet-activating factor synthesis by human monocytes stimulated with IL-1-β, tumor necrosis factor, or IFN-γ.
        J Immunol. 1988; 141: 3945-3950
        • Leaver HA
        • Qu JM
        • Smith G
        • et al.
        Endotoxin releases platelet-activating factor from human monocytes in vitro.
        Immunopharmacology. 1990; 20: 105-113
        • Droy-Lefaix M-T
        • Drouet Y
        • Gerard G
        • et al.
        Involvement of platelet-activating factor in rat ischemia reperfusion gastric damage.
        in: Braquet P Ginkgolides — Chemistry, Biology, Pharmacology and Clinical Perspectives. J R Prous Science Publishers, Barcelona1988: 563-574
        • Kubes P
        • Ibbotson G
        • Russell J
        • et al.
        Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence.
        Am J Physiol. 1990; 259: G300-G305
        • Filep J
        • Hermán F
        • Braquet P
        • et al.
        Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog.
        Biochem Biophys Res Commun. 1989; 158: 353-359
        • Montrucchio G
        • Alloatti G
        • Tetta C
        • et al.
        Release of platelet-activating factor from ischemic-reperfused rabbit heart.
        Am J Physiol. 1989; 256: H1236-H1246
        • Iwai A
        • Itoh M
        • Yokoyama Y
        • et al.
        Role of PAF in ischemia-reperfusion injury in the rat stomach.
        Scand J Gastroenterol. 1989; 24: 63-66
        • Wallace JL
        • Hogaboam CM
        • McKnight GW
        Platelet-activating factor mediates gastric damage induced by hemorrhagic shock.
        Am J Physiol. 1990; 259: G140-G146
        • Wallace JL
        • Cirino G
        • Nucci GD
        • et al.
        Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach.
        Am J Physiol. 1989; 256: G661-G666
        • Wallace JL
        • Keenan CM
        • Granger DN
        Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process.
        Am J Physiol. 1990; 259: G462-G467
        • Rainsford KD
        Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration.
        Pharmacol Res Commun. 1986; 18 (suppl): 209-215
        • Nogami M
        • Hoshihara Y
        • Tsubura K
        • et al.
        Effects of a platelet activating factor (PAF) antagonist CV-3988 on the acute gastric erosions of fats by water immersion and restrained stress, and by ethanol.
        Jpn J Gastroenterol. 1988; 85: 2149-2154
        • Söling H-D
        • Eibl H
        • Fest W
        Acetylcholine-like effects of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine (‘platelet-activating factor’) and its analogues in exocrine secretary glands.
        Eur J Biochem. 1984; 144: 65-72
        • Sugatani J
        • Steinhelper ME
        • Saito K
        • et al.
        Potential involvement of vicinal sulfhydryls in stimulus-induced rabbit platelet activation.
        J Biol Chem. 1987; 262: 16995-17001
        • Miwa M
        • Hill C
        • Kumar R
        • et al.
        Occurrence of an endogenous inhibitor of platelet-activating factor in rat liver.
        J Biol Chem. 1987; 262: 527-530
        • Nakayama R
        • Yasuda K
        • Saito K
        Existence of endogenous inhibitors of platelet-activating factor (PAF) with PAF in rat uterus.
        J Biol Chem. 1987; 262: 13174-13179
        • Sugatani J
        • Hughes KT
        • Miwa M
        • et al.
        Determination of PAF in biological samples by scintillation proximity radioimmunoassay.
        in: Tokyo PAF Symposium on Allergic, Respiratory and Cardiovascular Diseases, Tokyo1991: 49-50 (Abstract)
        • Yasuda K
        • Satouchi K
        • Nakayama R
        • et al.
        Acyl type platelet-activating factor in normal rat uterus determined by gas chromatography mass spectrometry.
        Biomed Environ Mass Spetrom. 1988; 16: 137-141
        • Satouchi K
        • Oda M
        • Saito K
        1-Acyl-2-acetyl-sn-glycero-3-phosphocholine from stimulated human polymorphonuclear leukocytes.
        Lipids. 1987; 22: 285-287
        • Oda M
        • Satouchi K
        • Yasunaga K
        • et al.
        Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187.
        J Immunol. 1985; 134: 1090-1093

      140. Sugatam J, Miwa M, Fujimura K et al. manuscript in preparation.

      141. Fujimura K, Sugatani J, Miwa M et al. manuscript in preparation.

        • Cho CH
        • Ogle CW
        Cholinergic-mediated gastric mast cell degranulation with subsequent histamine H1- and H2-receptor activation in stress ulceration in rats.
        Eur J Pharmacol. 1979; 55: 23-33
        • Oates PJ
        • Hakkinen JP
        Studies on the mechanism of ethanol-induced gastric damage in rats.
        Gastroenterology. 1988; 94: 10-21

      Article info

      Identification

      DOI: https://doi.org/10.1016/0952-3278(91)90048-A

      Copyright

      © 1991 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX