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The omega-6/omega-3 ratio is of importance!

Published:September 26, 2011DOI:https://doi.org/10.1016/j.plefa.2011.09.001
      In the paper of Guesnet et al. [
      • Guesnet P.
      • Lalalemand S.-M.
      • Alessandri J.-M.
      • Jouin M.
      • Cunnane S.-C.
      α-Linoleate reduces the dietary requirement for linoleate in the growing rat.
      ] in the present issue, the interaction between omega-6 and omega-3 fatty acids are illustrated in a thought-provoking way. It adds to the increasing evidence of a relation between the changes of this ratio in human and animal diets and the global epidemics of increases of metabolic complications as obesity, diabetes and neurological diseases. A recent paper analyzing the plurality of the obesity epidemics, Klimentidis et al. [
      • Klimentidis Y.C.
      • Beasley T.M.
      • Lin H.-Y.
      • Murati G.
      • Glass G.E.
      • Guyton M.
      • et al.
      Canaries in the coal mine: a cross-species analysis of the plurality of obesity epidemics.
      ] express their concern about that also primates, domestic and feral animals are developing obesity and furthermore that a similar trend is observed in laboratory animals. The interesting fact is that neither the fat content of the chow or the fat intake of the human population has increased over the latest decades [
      • Nguyen D.M.
      • El-Seraq H.B.
      The epidemiology of obesity.
      ], so other environmental causes are probably involved. In the humans special interest has been focused on less physical activity depending on the technical development worldwide, but this alone cannot explain the obesity epidemics, which also involve infants and the population in developing countries [
      • Klimentidis Y.C.
      • Beasley T.M.
      • Lin H.-Y.
      • Murati G.
      • Glass G.E.
      • Guyton M.
      • et al.
      Canaries in the coal mine: a cross-species analysis of the plurality of obesity epidemics.
      ]. It is certainly less likely in laboratory animals, whose living conditions have been rather the same for many decades.
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