Advertisement

In vivo magnetic resonance spectroscopy in chronic fatigue syndrome

  • A Chaudhuri
    Correspondence
    Corresponding author. Tel.: +44-141-201-2492; fax: +44-141-201-2993
    Affiliations
    Division of Clinical Neurosciences, Institute of Neurological Sciences, Southern General Hospital, University of Glasgow, 1345 Govan Road, Glasgow G51 4TF, UK
    Search for articles by this author
  • P.O Behan
    Affiliations
    Division of Clinical Neurosciences, Institute of Neurological Sciences, Southern General Hospital, University of Glasgow, 1345 Govan Road, Glasgow G51 4TF, UK
    Search for articles by this author

      Abstract

      The pathogenic mechanisms of chronic fatigue syndrome (CFS) are not clearly known. Fatigue, poor short-term memory and muscle pain are the most disabling symptoms in CFS. Research data on magnetic resonance spectroscopy (MRS) of muscles and brain in CFS patients suggest a cellular metabolic abnormality in some cases. 31P MRS of skeletal muscles in a subset of patients indicate early intracellular acidosis in the exercising muscles. 1H MRS of the regional brain areas in CFS have shown increased peaks of choline derived from the cell membrane phospholipids. Cell membrane oxidative stress may offer a common explanation for the observed MRS changes in the muscles and brain of CFS patients and this may have important therapeutic implications. As a research tool, MRS may be used as an objective outcome measure in the intervention studies. In addition, regional brain 1H MRS has the potential for wider use to substantiate a clinical diagnosis of CFS from other disorders of unexplained chronic fatigue.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Prostaglandins, Leukotrienes and Essential Fatty Acids
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Fukuda K
        • Strauss S.E
        • Hickie I
        • et al.
        The chronic fatigue syndrome.
        Ann. Intern. Med. 1994; 121: 953-959
        • Chaudhuri A
        • Behan W.M.H
        • Behan P.O
        Chronic fatigue syndrome.
        Proc. R. Coll. Physician Edinburgh. 1998; 28: 150-163
      1. D.L. Arnold, P.J. Bore, G.K. Radda, P. Styles, D.J. Taylor, Excessive intracellular acidosis of skeletal muscles in exercise in a patient with a postviral exhaustion fatigue syndrome, Lancet i (1984) 1367–1369

      2. D.L. Arnold, P.J. Bore, G.K. Radda, P. Styles, D.J. Taylor, Excessive intracellular acidosis of skeletal muscle on exercise in the post-viral exhaustion/fatigue syndrome: a 31P NMR study, Proceedings of the Third Annual Meeting of the Society for Magnetic Resonance in Medicine, New York, 1984, pp. 12–13.

        • Barnes P.R.J
        • Taylor D.J
        • Kemp G.J
        • Radda G.K
        Skeletal muscle bioenergetics in the chronic fatigue syndrome.
        J. Neurol. Neurosurg. Psychiat. 1993; 56: 679-683
      3. R. Wong, G. Lopsachuk, G. Zhu, et al., Skeletal muscle metabolism in chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy, Chest 102 (1992) 1716–1722.

        • McCully K.K
        • Natelson B.H
        • Iotti S
        • Sisto S
        • Leigh Jr., J.S
        Reduced oxidative muscle metabolism in chronic fatigue syndrome.
        Muscle Nerve. 1996; 19: 621-625
        • Lane R.J.M
        • Woodrow D
        • Archard L.C
        Lactate responses to exercise in chronic fatigue syndrome.
        J. Neurol. Neurosurg. Psychiat. 1994; 57: 375-376
        • Lane R.J.M
        • Barnett M.C
        • Taylor D.J
        • Kemp G.J
        • Lodi R
        Heterogeneity in chronic fatigue syndrome.
        Neuromuscular Disord. 1998; 8: 204-209
        • Chaudhuri A
        • Watson W.S
        • Behan P.O
        Arguments for a role of abnormal ionophore function in chronic fatigue syndrome.
        in: Yehuda S Mostofsky D.I Chronic Fatigue Syndrome. Plenum Press, New York1997: 135-142
        • Buchthal S.D
        • den Hollander J.A
        • Merz C.N.B
        • et al.
        Abnormal myocardial phosphorus-31 nuclear magnetic resonance spectroscopy in women with chest pain but normal coronary angiograms.
        N. Engl. J. Med. 2000; 342: 829-835
        • Brooks J.C.W
        • Roberts N
        • Whitehouse G
        • Majeed T
        Proton magnetic resonance spectroscopy and morphometry of hippocampus in chronic fatigue syndrome.
        Br. J. Radiol. 2000; 73: 1206-1208
        • Puri B.K
        • Counsell S.J
        • Zaman R
        • et al.
        Relative increase in choline in the occipital cortex in chronic fatigue syndrome.
        Acta. Psychiatr. Scand. 2002; 106: 224-226
        • Chaudhuri A
        • Condon B.R
        • Gow J.W
        • Brennan D
        • Hadley D.M
        Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome.
        Neuroreport. 2003; 14: 225-228
        • Tomoda A
        • Miike T
        • Yamada E
        • et al.
        Chronic fatigue syndrome in childhood.
        Brain Dev. 2000; 22: 60-64
        • Brand A
        • Reichter-Landsberg C
        • Leibfritz D
        Multinuclear NMR studies on the energy metabolism of glial and neuronal cells.
        Dev. Neurosci. 1993; 15: 289-298
        • Moore C.M
        • Breeze J.L
        • Gruber S.A
        • et al.
        Choline, myo-inositol and mood in bipolar disorder.
        Bipolar Disord. 2000; 2: 207-216
        • Carrasco L
        Modification of membrane permeability by animal viruses.
        in: Advances in Virus Research. Vol. 45. Academic Press, New York1995: 61-112
      4. D.F. Horrobin, C.N. Bennett, Phospholipid metabolism and the pathophysiology of psychiatric and neurological disorders, in: M. Peet, I. Glen, D.F. Horrobin (Eds.), Phospholipid Spectrum Disorders in Psychiatry and Neurology, 2nd Edition, Marius Press, Canforth, 2003, pp. 3–48.

        • Chaudhuri A
        • Watson W.S
        • Pearn J
        • Behan P.O
        Symptoms of chronic fatigue syndrome are due to abnormal ion channel function.
        Med. Hypotheses. 2000; 54: 59-63
        • Watson W.S
        • Chaudhuri A
        • McCreath G.T
        • Behan P.O
        A possible cell membrane defect in chronic fatigue syndrome and syndrome X.
        in: Kaski J.C Chest Pain with Normal Coronary Angiograms: Pathogenesis, Diagnosis and Management. Kluwer Academic, London1999: 143-149