Abstract
Metformin improves insulin sensitivity, which is correlated to phospholipid fatty
acid composition in obese type 2 diabetics. We aimed at investigating the relationship
between Metformin and fatty acids in obese insulin resistant non-diabetic individuals. A double-blind, placebo-controlled 20-week trial was performed in 21
BMI and age-matched insulin resistant non-diabetic individuals receiving either Metformin or placebo. Insulin sensitivity together with
metabolic parameters and fatty acids in serum phospholipids were measured at baseline
and at 20 weeks. A significant decrease in body weight, BMI, percentage body fat,
the sum of saturated fatty acids in serum phospholipids and increase in insulin sensitivity
index were observed following the 20-week treatment. These changes did not differ
significantly between the groups. Energy restriction rather than Metformin treatment
appears to be responsible for the observed changes. The associations previously found
in diabetics between insulin sensitivity and phospholipid fatty acids may not be mediated
by Metformin.
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Published online: October 11, 2004
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© 2004 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
