Abstract
The present study was undertaken to replicate an association between the PTGS2/PLA2G4A
locus and schizophrenia among a Chinese population. We recruited 168 Chinese parent–offspring
trios of Han descent, consisting of fathers, mothers and affected offspring with schizophrenia.
Of 3 informative SNPs genotyped, no one showed allelic association with schizophrenia;
the haplotype analysis also failed to capture a haplotypic association with the illness.
Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese
population as compared with a British population that initially showed the genetic
association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background
may be a major reason for poor replication of the initial finding.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Prostaglandins, Leukotrienes and Essential Fatty AcidsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The distribution of phospholipid fractions in the red cell membrane of schizophrenics.Schizophr. Bull. 1972; 6: 60-61
- Defects in transmethylation and membrane lipids in schizophrenia.Psychopharmacol. Bull. 1983; 19: 594-599
- Membrane abnormalities in the psychosis and affective disorders.J. Psychiatr. Res. 1984; 18: 319-326
- Erythrocyte membrane phospholipids in psychotic patients.Psychiatl. Res. 1993; 49: 89-95
- A red cell membrane abnormality in a subgroup of schizophrenic patients.Evidence for two diseases. Schizophr. Res. 1994; 12: 53-61
- Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex in vivo phosphorus 31 nuclear magnetic resonance spectroscopy.Arch. Gen. Psychiatr. 1991; 48: 563-568
- Study of chronic schizophrenics using 31P magnetic resonance chemical shift imaging.Acta. Psychiatr. Scand. 1992; 86: 455-462
- Membrane phospholipid metabolism and schizophrenia, an in vivo 31P-MR spectroscopy study.Schizophr. Res. 1994; 13: 209-215
- An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy.Arch. Gen. Psychiatr. 1995; 52: 399-406
- et al. A 1H-decoupled 31P chemical shift imaging study of medicated schizophrenic patients and healthy controls,.Biol. Psychiatr. 1999; 45: 687-693
- Cerebral phosphate metabolism in first-degree relatives of patients with schizophrenia.Am. J. Psychiatr. 2001; 158: 958-960
- Genetic vairiant near cytosolic phospholipase A2 associated with schizophrenia.Schizophr. Res. 1996; 21: 111-116
- Association of the Ban I dimorphic site at the human cytosolic phospholipase A2 gene with schizophrenia.Psychiatr. Genet. 1998; 8: 191-192
- Is the cPLA2 gene associated with schizophrenia?.Mol. Psychiatr. 1998; 3: 480-482
- A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia.Prostaglandins Leukot. Essent. Fatty Acids. 2004; 70: 413-415
- The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker.Neuropsychobiology. 2003; 47: 115-119
- Lack of association between schizophrenia and a polymorphism close to the cytosolic phospholipase A2 gene.Psychiatr. Genet. 1997; 7: 111-114
- Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent family based samples.Psychiatr. Genet. 2001; 11: 207-212
- Lack of association between schizophrenia and the phospholipase-A (2) genes cPLA2 and sPLA2.Am. J. Med. Genet. 2001; 105: 246-249
- Histamine and prostaglandins in schizophrenia.Med. Hypotheses. 1999; 52: 37-42
- Niacin skin flush in schizophrenia.Schizophr. Res. 1998; 29: 269-274
- The niacin skin flush test in schizophrenia.Int. J. Clin. Pract. 2001; 55: 368-370
- A volumetric biochemical niacin flush-based index that noninvasively detects fatty acid deficiency in schizophrenia.Prog. Neuropsychopharmacol. Biol. Psychiatr. 2002; 26: 49-52
- The niacin skin flush abnormality in schizophrenia.Schizophr. Res. 2003; 62: 251-258
The International SNP Map Working Group. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms, Nature 409 (2001) 928–933.
Article info
Publication history
Published online: October 11, 2004
Accepted:
September 1,
2004
Received:
April 15,
2004
Identification
Copyright
© 2004 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
