Abstract
Background
Essential hypertension (EH) is a complex multifactorial polygenic disorder that is
thought to result from an interaction between an individual's genetic makeup and various
environmental factors. In the kidney, prostaglandins (PGs) are important mediators
of vascular tone and salt and water homeostasis, and are involved in the mediation
and/or modulation of hormonal action. In previous studies, mice deficient in the prostaglandin
E2 (PGE2) EP2 receptor had resting systolic blood pressure (BP) that was significantly lower
than that of wild-type controls. The BP of those mice increased when they were put
on a high-salt diet, suggesting that the EP2 receptor is involved in sodium handling
by the kidney. In the present study, we investigated the association between EH and
nucleotide polymorphisms in the gene encoding the prostaglandin E2 receptor subtype
EP2 (PTGER2).
Methods
We selected three single-nucleotide polymorphisms (SNP) in the human PTGER2 gene (rs1254601,
rs2075797, and rs17197), and we performed a genetic association study of 266 EH patients
and 253 age-matched normotensive (NT) controls.
Results
There was no significant difference in overall distribution of genotypes or alleles
of any of the SNP between the EH and NT groups. However, among men, the A/A type of
the SNP rs17197 (rs17197, A/G in 3′UTR) was significantly more frequent in EH subjects
than in NT subjects (P=0.041).
Conclusion
The present findings suggest that rs17197 is useful as a genetic marker of EH in men.
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Article info
Publication history
Published online: July 19, 2007
Accepted:
April 4,
2007
Received in revised form:
March 30,
2007
Received:
November 17,
2006
Identification
Copyright
© 2007 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
