Abstract
The effects of canola-type rapeseed oil (RSO) on serum lipids, plasma fibrinogen,
lipid oxidation and fatty acids were studied in three groups of subjects, two of which
had not been consuming fish in their habitual diets. Forty-two volunteers (35 women,
7 men, 16–62 years) replaced fat with RSO for 6 weeks in a parallel design. The average
cholesterol and fibrinogen concentrations were 5.0 mmol/l and 2.6 g/l, respectively. The intake of α-linolenic acid (α-LLA) was doubled. Efficient competitive
inhibition by α-LLA was seen as a decrease in long-chain (LC) n-6 PUFA at 3 weeks.
Elevated fibrinogen (2.6–3.9 g/l) decreased by 0.95 g/l at 6 weeks. Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at
low fibrinogen levels only. The associations and changes in plasma C18 and LC PUFA
followed the competitive and metabolic principles of the body, and especially in the
case of n-3 PUFA according to the recycling pathway.
Keywords
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Article info
Publication history
Published online: March 08, 2010
Accepted:
February 2,
2010
Received in revised form:
November 23,
2009
Received:
December 20,
2008
Identification
Copyright
© 2010 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
