Abstract
Introduction
Long-chain polyunsaturated (LCP) fatty acids (FA) are important during infant development.
Mother-to-infant FA-transport occurs at the expense of the maternal status. Maternal
and infant FA-status change rapidly after delivery.
Methods
Comparison of maternal (mRBC) and infant erythrocyte (iRBC)-FA-profiles at delivery
and after 3 months exclusive breastfeeding in relation to freshwater-fish intakes.
Approximation of de-novo-lipogenesis (DNL), stearoyl-CoA-desaturase (SCD), elongation-of-very-long-chain-FA-family-member-6
(Elovl-6), delta-5-desaturase (D5D) and delta-6-desaturase (D6D)-enzymatic activities
from their product/essential-FA and product/substrate-ratios.
Results and discussion
Increasing iRBC-14:0 derived from mammary-gland DNL. Decreasing mRBC-ω9, but increasing
iRBC-ω9, suggest high ω9-FA-transfer via breastmilk. Decreasing (m+i)RBC-16:0, DNL-
and SCD-activities, but increasing (m+i)RBC-18:0 and Elovl-6-activity suggest more
pronounced postpartum decreases in DNL- and SCD-activities, compared to Elovl-6-activity.
Increasing (m+i)RBC-18:3ω3, 20:5ω3, 22:5ω3, 18:2ω6, mRBC-20:4ω6 and (m+i)D5D-activity,
but decreasing mRBC-22:6ω3 and (m+i)D6D-activity and dose-dependent changes in iRBC-22:6ω3
confirm that D6D-activity is rate-limiting and 22:6ω3 is important during lactation.
Fish-intake related magnitudes of postpartum FA-changes suggest that LCPω3 influence
DNL-, SCD- and desaturase-activities.
Abbreviations:
AA (arachidonic acid), ACC (acetyl-Coenzyme A carboxylase), ALA (α-linolenic acid), ChREBP (carbohydrate responsive element binding protein), DHA (docosahexaenoic acid), DNL (de novo lipid synthesis or de novo lipogenesis), EFA (essential fatty acids), Elovl-6 (elongation of very long chained fatty acids family member 6), EPA (eicosapentaenoic acid), FA (fatty acids), FADS (fatty acid desaturase), FAS (fatty acid synthase), LA (linoleic acid), LXR (liver-X-receptor), MUFA (monounsaturated fatty acids), RBC (erythrocyte), PP (postpartum), PUFA (polyunsaturated fatty acids), SAFA (saturated fatty acids), SCD-1 (stearoyl-coenzyme A desaturase family member 1), SREBP-1 (sterol regulatory element binding protein-1), VLDL (very low density lipoprotein.)Keywords
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Article info
Publication history
Published online: September 14, 2011
Accepted:
June 24,
2011
Received in revised form:
June 9,
2011
Received:
February 23,
2011
Identification
Copyright
© 2011 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
