Abstract
This study determined the sensitivity of heart and brain arachidonic acid (ARA) and
docosahexaenoic acid (DHA) to the dietary ARA level in a dose–response design with
constant, high DHA in neonatal piglets. On day 3 of age, pigs were assigned to 1 of
6 dietary formulas varying in ARA/DHA as follows (% fatty acid, FA/FA): (A1) 0.1/1.0;
(A2) 0.53/1.0; (A3–D3) 0.69/1.0; (A4) 1.1/1.0; (D2) 0.67/0.62; and (D1) 0.66/0.33.
At necropsy (day 28) higher levels of dietary ARA were associated with increased heart
and liver ARA, while brain ARA remained unaffected. Dietary ARA had no effect on tissue
DHA accretion. Heart was particularly sensitive, with pigs in the intermediate groups
having different ARA (A2, 18.6±0.7%; A3, 19.4±1.0%) and a 0.17% increase in dietary
ARA resulted in a 0.84% increase in heart ARA. Further investigations are warranted
to determine the clinical significance of heart ARA status in developing neonates.
Abbreviations:
ARA (arachidonic acid), DHA (docosahexaenoic acid), FA (fatty acid), FAME (FA methyl ester), FR (formula-reared), LCPUFA (long chain polyunsaturated fatty acid), MR (maternal-reared)Keywords
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Article info
Publication history
Published online: September 01, 2011
Accepted:
August 12,
2011
Received in revised form:
August 11,
2011
Received:
June 20,
2011
Footnotes
☆This project was also supported in part by Award T32DK007158 from the National Institute of Diabetes and Digestive and Kidney Diseases of the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
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© 2011 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
