Abstract
To investigate the association between the polymorphisms of fatty acid desaturase
1 (FADS1), fatty acid desaturase 2 (FADS2) and elongation of very long chain fatty acids like 2 (ELOVL2) gene and coronary artery disease (CAD) in a Chinese Han population. Three single
nucleotide polymorphisms (SNPs) from these genes were genotyped using PCR-based restriction
fragment length polymorphism analysis in 199 CAD cases and 192 controls of Han Chinese
origin. rs174556 in the FADS1 gene showed allelic (P=0.002) and genotypic (P=0.030) association with the disease, while there was no disease association for the
other two SNPs. The frequency of rs174556 minor allele (T) was significantly higher
in the case group than the control group. The trans phase gene–gene interaction analysis
showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was weakly
associated with the disease (P=0.043). rs174556 in the FADS1 gene is very likely to be associated with CAD in the Chinese Han population.
List of abbreviations:
CAD (coronary artery disease), FADS1 (fatty acid desaturase 1), FADS2 (fatty acid desaturase 2), ELOVL2 (elongation of very long chain fatty acids (fen1/elo2, sur4/elo3, yeast)-like 2), PUFA (polyunsaturated fatty acids), D5D (Δ5 desaturase), D6D (Δ6 desaturase), ALA (α-linolenic acid), ARA (arachidonic acid), DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), DPA (docosapentaenoic acid), LA (linoleic acid), SNP (single nucleotide polymorphism)Keywords
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Article info
Publication history
Published online: September 14, 2011
Accepted:
August 25,
2011
Received in revised form:
June 20,
2011
Received:
May 18,
2011
Identification
Copyright
© 2011 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
