Abstract
Preterms need supplementation with docosahexaenoic (DHA) and arachidonic (AA) acids
to prevent steep postnatal declines.
Associations between growth and erythrocyte (RBC) DHA and AA were studied in 139 preterms
(51% male, gestational age 30.3±1.5 weeks, birth weight 1341±288 g) fed human milk with breast milk fortifier or preterm formula until term, followed
by postdischarge formula (PDF; n=52, 0.4% DHA, 0.4% AA), term formula (TF; n=41, 0.2% DHA, 0.2% AA), or human milk (HM; n=46).
At six months, PDF resulted in higher RBC-DHA than TF and HM, while RBC-AA was higher
than TF, but similar to HM. There were no between-group differences in growth between
term and six months. RHC-DHA related positively with gain in weight and length and
negatively with gain in head circumference. RBC-AA related positively with gain in
head circumference and negatively with gain in weight and length.
In conclusion, PDF with higher DHA and AA than TF may promote postnatal growth of
preterms.
Keywords
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Article info
Publication history
Published online: October 13, 2011
Accepted:
September 19,
2011
Received in revised form:
September 13,
2011
Received:
June 15,
2011
Footnotes
☆This study was supported by an unrestricted research grant from FrieslandCampina [registered trademark], Leeuwarden, The Netherlands.
☆☆Clinical trial registration information: Study Towards the Effects of Postdischarge Nutrition on Growth and Body Composition of Infants Born Less Than or Equal to 32 Weeks Gestation and/or Less Than or Equal to 1500 Gram Birth weight. URL: www.isrctn.org. Unique identifier ISRCTN 53695702.
Identification
Copyright
© 2011 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
