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Fish oil-supplementation from 9 to 12 months of age affects infant attention in a free-play test and is related to change in blood pressure

Published:September 16, 2013DOI:https://doi.org/10.1016/j.plefa.2013.08.007

      Abstract

      Introduction

      This intervention examined whether fish-oil-supplementation in late infancy modifies free-play test scores and if this is related to blood pressure (BP) and mean RR interval.

      Patients and methods

      83 Danish 9-month-old infants were randomized to ±fish oil (FO) (3.4±1.1 mL/d) for 3 months and 61 of these completed the free-play-test before and after the intervention.

      Results

      Most of the free-play scores changed during the intervention, but the intervention affected only the number of looks away from the toy, which was increased in +FO and decreased in −FO (p=0.037). The increased numbers of looks away were associated with an increase in erythrocyte eicosapentaenoic acid (r=0.401, p=0.017, n=35) and were also associated with a decrease in systolic-BP (r=−0.511, p<0.001, n=52).

      Conclusions

      The results indicate that n-3 fatty acid intake also in late infancy can influence brain development and that the cognitive and cardiovascular effects may be related.

      Abbreviations:

      ANS (autonomic nervous system), BP (blood pressure (systolic SBP & diastolic DBP)), CNS (central nervous system), DHA (docosahexaenoic acid), ECG (electro-cardiogram), EPA (eicosapentaenoic acid), FA% (fatty acids given as area percentage), FO (fish oil), HR (heart rate), LCPUFA (long-chain polyunsaturated fatty acid), RBC (red blood cell)

      Keywords

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