Advertisement

Docosahexaenoic acid supplementation (DHA) and the return on investment for pregnancy outcomes

      Highlights

      • Early preterm birth (ePTB) occurs before 34 weeks gestation.
      • ePTB cost the US approximately USD 10.6 Billion in 2014.
      • Public policy effort to increase DHA intake of pregnant women is important.

      Abstract

      The Kansas University DHA Outcomes Study (KUDOS) found a significant reduction in early preterm births with a supplement of 600 mg DHA per day compared to placebo. The objective of this analysis was to determine if hospital costs differed between groups. We applied a post-hoc cost analysis of the delivery hospitalization and all hospitalizations in the following year to 197 mother-infant dyads who delivered at Kansas University Hospital. Hospital cost saving of DHA supplementation amounted to $1678 per infant. Even after adjusting for the estimated cost of providing 600 mg/d DHA for 26 weeks ($166.48) and a slightly higher maternal care cost ($26) in the DHA group, the net saving per dyad was $1484. Extrapolating this to the nearly 4 million US deliveries per year suggests universal supplementation with 600 mg/d during the last 2 trimesters of pregnancy could save the US health care system up to USD 6 billion.

      Abbreviations:

      DHA (Docosahexaenoic acid), DRG (Diagnosis-related group), ePTB (Early preterm birth), HCUP (Healthcare Cost and Utilization Project), KUDOS (Kansas University DHA Outcomes Study), DOMInO (DHA to Optimize Mother and Infant Outcome)

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Prostaglandins, Leukotrienes and Essential Fatty Acids
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. B.E. Hamilton, J.A. Martin, M.J. Osterman, S.C. Curtin, T.J. Matthews, Births: Final Data for 2014, National Vital Statistics Reports: from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System, vol. 64, 2015, pp. 1–64.

      2. B. Institute of Medicine Committee on Understanding Premature, O. Assuring Healthy, The National Academies collection: reports funded by National Institutes of Health, in: R.E. Behrman, A.S. Butler (Eds.) Preterm Birth: Causes, Consequences, and Prevention, National Academies Press (US), National Academy of Sciences, Washington (DC), 2007.

        • Makrides M.
        • Gibson R.A.
        • McPhee A.J.
        • Yelland L.
        • Quinlivan J.
        • Ryan P.
        Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial.
        Jama. 2010; 304: 1675-1683
        • Carlson S.E.
        • Colombo J.
        • Gajewski B.J.
        • Gustafson K.M.
        • Mundy D.
        • Yeast J.
        • Georgieff M.K.
        • Markley L.A.
        • Kerling E.H.
        • Shaddy D.J.
        DHA supplementation and pregnancy outcomes.
        Am. J. Clin. Nutr. 2013; 97: 808-815
        • Kar S.
        • Wong M.
        • Rogozinska E.
        • Thangaratinam S.
        Effects of omega-3 fatty acids in prevention of early preterm delivery: a systematic review and meta-analysis of randomized studies.
        Eur. J. Obstet. Gynecol. Reprod. Biol. 2016; 198: 40-46
        • Ahmed S.
        • Makrides M.
        • Sim N.
        • McPhee A.
        • Quinlivan J.
        • Gibson R.
        • Umberger W.
        Analysis of hospital cost outcome of DHA-rich fish-oil supplementation in pregnancy: evidence from a randomized controlled trial.
        Prostaglandins Leukot. Essent. Fat. Acids. 2015; 102–103: 5-11
        • Mangham L.J.
        • Petrou S.
        • Doyle L.W.
        • Draper E.S.
        • Marlow N.
        The cost of preterm birth throughout childhood in England and Wales.
        Pediatrics. 2009; 123: e312-e327