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Full length article| Volume 111, P8-10, August 01, 2016

Docosahexaenoic acid supplementation (DHA) and the return on investment for pregnancy outcomes

Published:May 13, 2016DOI:https://doi.org/10.1016/j.plefa.2016.05.008
Docosahexaenoic acid supplementation (DHA) and the return on investment for pregnancy outcomes
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      Highlights

      • •
        Early preterm birth (ePTB) occurs before 34 weeks gestation.
      • •
        ePTB cost the US approximately USD 10.6 Billion in 2014.
      • •
        Public policy effort to increase DHA intake of pregnant women is important.

      Abstract

      The Kansas University DHA Outcomes Study (KUDOS) found a significant reduction in early preterm births with a supplement of 600 mg DHA per day compared to placebo. The objective of this analysis was to determine if hospital costs differed between groups. We applied a post-hoc cost analysis of the delivery hospitalization and all hospitalizations in the following year to 197 mother-infant dyads who delivered at Kansas University Hospital. Hospital cost saving of DHA supplementation amounted to $1678 per infant. Even after adjusting for the estimated cost of providing 600 mg/d DHA for 26 weeks ($166.48) and a slightly higher maternal care cost ($26) in the DHA group, the net saving per dyad was $1484. Extrapolating this to the nearly 4 million US deliveries per year suggests universal supplementation with 600 mg/d during the last 2 trimesters of pregnancy could save the US health care system up to USD 6 billion.

      Abbreviations:

      DHA (Docosahexaenoic acid), DRG (Diagnosis-related group), ePTB (Early preterm birth), HCUP (Healthcare Cost and Utilization Project), KUDOS (Kansas University DHA Outcomes Study), DOMInO (DHA to Optimize Mother and Infant Outcome)

      Keywords

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      References

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      Article Info

      Publication History

      Published online: May 13, 2016
      Accepted: May 12, 2016
      Received in revised form: May 11, 2016
      Received: April 5, 2016

      Footnotes

      ☆Supported by a grant from the National Institutes of Health (HD047315). DSM, Columbia, Maryland, USA donated the investigational capsules.

      ☆☆Clinical trial registry: ClinicalTrials.gov identifier: NCT00266825.

      Identification

      DOI: https://doi.org/10.1016/j.plefa.2016.05.008

      Copyright

      © 2016 Elsevier Ltd. All rights reserved.

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