Highlights
- •Lipid peroxidation has been reported to occur in plasma of cystic fibrosis (CF) patients.
- •Moderate intake of docosahexaenoic acid (DHA) may lower oxidative stress.
- •Plasma and platelet vitamin E increased after moderate intake of DHA in CF patients.
- •Our study supports the antioxidant potential of moderate DHA intake in CF patients.
Abstract
Patients with cystic fibrosis have increased oxidative stress and impaired antioxidant
systems. Moderate intake of docosahexaenoic acid (DHA) may favor the lowering of oxidative
stress. In this randomized, double-blind, cross-over study, DHA or placebo capsules,
were given daily to 10 patients, 5 mg/kg for 2 weeks then 10 mg/kg DHA for the next 2 weeks (or placebo). After 9 weeks of wash-out, patients took
placebo or DHA capsules. Biomarkers of lipid peroxidation and vitamin E were measured
at baseline, and after 2 and 4 weeks of treatment in each phase. The proportions of
DHA increased both in plasma and platelet lipids after DHA supplementations. The lipid
peroxidation markers did not significantly decrease, in spite of a trend, after the
first and/or the second dose of DHA but plasma and platelet vitamin E amounts increased
significantly after DHA supplementation. Our findings reinforce the antioxidant potential
of moderate DHA intake in subjects displaying increased oxidative stress.
Abbreviations:
CF (cystic fibrosis), CFTR (cystic fibrosis trans-membrane conductance regulator), TxB2 (thromboxane B2)Keywords
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Article info
Publication history
Published online: October 18, 2016
Accepted:
October 17,
2016
Received in revised form:
October 17,
2016
Received:
June 27,
2016
Identification
Copyright
© 2016 Elsevier Ltd. All rights reserved.
