Highlights
- •We investigated the role of PLA2G6 and PLA2G4C gene polymorphisms in schizophrenia.
- •The investigated polymorphisms alone do not contribute to schizophrenia risk/onset.
- •The interaction between the polymorphisms contributes to schizophrenia risk.
- •The PLA2G4C polymorphism alone influences psychopathology data in males.
- •The PLA2G6/PLA2G4C interaction also influences psychopathology data in males.
Abstract
We investigated the allele and genotype frequency of the rs4375 and rs1549637 polymorphisms
in phospholipase A2 (PLA2)G6 and PLA2G4C genes in 203 patients with schizophrenia
and 191 controls in a Croatian population. We hypothesized that these polymorphic
variations might influence the age of schizophrenia onset and Positive and Negative
Syndrome Scale psychopathology (PANSS) data. We detected a significant overrepresentation
of the PLA2G6-CT and PLA2G4C-AT genotype combination in patients compared with controls
(14.7% vs. 7.3%, P < 0.05). The combined PLA2G6/PLA2G4C heterozygosity was associated
with about a two-fold higher schizophrenia risk. We found no significant influence
of the PLA2G6 and PLA2G4C polymorphisms on mean age at first hospital admission (P
> 0.05) and that the investigated polymorphisms significantly influenced the clinical
psychopathology only in male patients. The PLA2G4C polymorphism accounted for approximately
12% of negative symptom severity; whereas, the PLA2G6/PLA2G4C interaction contributed
to a similar extent to total PANSS symptom variations.
Abbreviations:
ANOVA (one-way analysis of variance), ARA (arachidonic acid (20:4n-6)), CI (confidence interval), OR (odds ratio), PLA2 (phospholipase A2), iPLA2β (calcium-independent phospholipase A2 beta), cPLA2γ (cytosolic phospholipase A2 gamma), PANSS (Positive and Negative Syndrome Scale), χ2 test (chi square test)Keywords
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Article info
Publication history
Published online: June 13, 2017
Accepted:
June 12,
2017
Received in revised form:
March 30,
2017
Received:
November 10,
2016
Identification
Copyright
© 2017 Elsevier Ltd. All rights reserved.
