Highlights
- •We investigated for the first time the relationship between the intake of 19 different dietary fatty acids and rheumatoid arthritis in a relatively large sample size of the population.
- •Among the 19 dietary fatty acids, only 4 subclasses (hexadecanoic acid, octadecanoic acid, hexadecenoic acid, and docosahexaenoic acid) were significantly associated with Hs-CRP or RA risk.
- •We found the inverted U-shaped relationship between MUFAs and RA risk, which may provide insights for future interventional studies to find potential treatment or prevention strategies for RA.
Abstract
Background
The relationship between dietary fatty acid intakes and rheumatoid arthritis (RA)
is unclear and the available studies have focused on only a few fatty acids. This
study investigated the association between the intake of 19 dietary fatty acids and
RA in U.S. adults.
Methods
This cross-sectional study using nationally representative data from the 2010-2020
National Health and Nutrition Examination Survey (NHANES). Multivariate linear regression
model, multivariate logic regression models, smoothing curve fitting, and two-segment
linear regression model were used to explore the relationships between 19 dietary
fatty acids intakes with high-sensitivity C-reactive protein (Hs-CRP) and RA risk.
Results
A total of 16,530 participants were included (1053 participants with RA). Intake of
hexadecanoic acid and octadecanoic acid were significantly associated with higher
Hs-CRP levels, intake of hexadecenoic acid was significantly associated with higher
RA risk, and intake of docosahexaenoic acid was significantly associated with lower
RA risk. In addition, there was an inverted U-shaped relationship between total monounsaturated
fatty acids (MUFAs) intake and RA risk, with the inflection point reached at 15.77%
.
Conclusions
Among the 19 dietary fatty acids, only 4 subclasses were significantly associated
with Hs-CRP or RA risk. The inverted U-shaped relationship between MUFAs and RA risk
may provide insights to find potential prevention strategies for RA.
Keywords
Abbreviations:
Rheumatoid arthritis ((RA)), National Health and Nutrition Examination Survey ((NHANES)), High-sensitivity C-reactive protein ((Hs-CRP)), Saturated fatty acids ((SFAs)), Monounsaturated fatty acids ((MUFAs)), Polyunsaturated fatty acids ((PUFAs)), Short-chain fatty acids ((SCFAs)), SFA 4:0 ((Butanoic)), SFA 6:0 ((Hexanoic)), SFA 8:0 ((Octanoic)), SFA 10:0 ((Decanoic)), SFA 12:0 ((Dodecanoic)), SFA 14:0 ((Tetradecanoic)), SFA 16:0 ((Hexadecanoic)), SFA 18:0 ((Octadecanoic)), MUFA 18:0 ((Hexadecenoic)), MUFA 18:1 ((Octadecenoic)), MUFA 20:1 ((Eicosenoic)), MUFA 22:1 ((Docosenoic)), PUFA 18:2 ((Octadecadienoic)), PUFA 18:3 ((Octadecatrienoic)), PUFA 18:4 ((Octadecatetraenoic)), PUFA 20:4 ((Eicosatetraenoic)), PUFA 20:5 ((Eicosapentaenoic)), PUFA 22:5 ((Docosapentaenoic)), PUFA 22:6 ((Docosahexaenoic)), Arthritis in older adults ((ARTIEL))To read this article in full you will need to make a payment
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Article info
Publication history
Published online: December 26, 2022
Accepted:
December 23,
2022
Received in revised form:
November 30,
2022
Received:
October 9,
2022
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
