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Abstract
Eicosanoids have been implicated in the pathogenesis of cancer and are known to regulate
the expression of antigens of the major histocompatibility complex (MHC). In human
colon cancer, we have recently observed that: (a) the expression of MHC class I and
II antigens are markedly reduced; and (b) the levels of PGE2, but not of PGF2α and LTB4, are elevated compared to histologically normal mucosa. Therefore, we investigated
the effect of PGE2, PGF2α and LTB4 on the regulation of MHC class I antigens in two human colon adenocarcinoma cell
lines and in a murine model of colon cancer. None of these eicosanoids had any significant
effect on the expression of MHC class I antigens in the human colonocytes or the transcription
rate of class I genes, with the exception of LTB4 which only modestly suppressed the transcription rate. Similarly, 16,16-dimethyl-PGE2 had no effect on the expression of MHC class I genes in the colonocytes of ![Math Eq]()
mice treated with the carcinogen dimethylhydrazine. We conclude that PGE2, PGf2α and LTB4 did not affect the expression of MHC class I antigens in cultured human colon adenocarcinoma
cells, and 16,16-dimethyl PGE2 did not affect their expression in mice, even when mice were treated with a colon
carcinogen. Thus, these eicosanoids are an unlikely regulator of the observed underexpression
of MHC class I antigens in human colon cancer.
mice treated with the carcinogen dimethylhydrazine. We conclude that PGE2, PGf2α and LTB4 did not affect the expression of MHC class I antigens in cultured human colon adenocarcinoma
cells, and 16,16-dimethyl PGE2 did not affect their expression in mice, even when mice were treated with a colon
carcinogen. Thus, these eicosanoids are an unlikely regulator of the observed underexpression
of MHC class I antigens in human colon cancer.To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
May 16,
1995
Received:
May 15,
1995
Identification
Copyright
© 1996 Published by Elsevier Inc.
