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Abstract
To investigate the possible mechanism of the therapeutic action of propolis, we studied:
(a) the effect of propolis, its components, caffeic acid phenethyl ester (CAPE), caffeic
acid (CA), quercetin and naringenin, as well as the synthetic compounds indomethacin
(IM) and nordihydroguaiaretic acid (NDGA), and a novel lipoxygenase inhibitor N,N′-dicyclohexyl-O-(3,4-dihydroxycinnamoyl)isourea (DCHCU) on eicosanoid production by mouse peritoneal
macrophages in vitro; (b) the effect of IM, NDGA, CA, CAPE, DCHCU and propolis on
eicosanoid production during acute inflammation in vivo; and (c) the ex vivo and in
vivo effect of dietary propolis on arachidonic acid metabolism. The ethanol extract
of propolis suppressed prostaglandin and leukotriene generation by murine peritoneal
macrophages in vitro and during zymosan-induced acute peritoneal inflammation in vivo.
Dietary propolis significantly suppressed the lipoxygenase pathway of arachidonic
acid metabolism during inflammation in vivo. CAPE was the most potent modulator of
the arachidonic acid cascade among the propolis components examined.
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References
- Lipoxin biosynthesis and its impact in inflammatory and vascular events.Biochim Biophys Acta. 1994; 1212: 1-25
- Leukotrienes and lipoxins: structures, biosynthesis and biological effects.Science. 1987; 237: 1171-1176
- An elucidation of the arachidonic acid cascade discovery of prostaglandins, thromboxane and leukotrienes.Drugs. 1987; 33: 2-9
- Dietary polyunsaturated fatty acids and eicosanoids: potential effects on the modulation of inflammatory and immune cells: an overview.Nutrition. 1990; 6: 24-44
- Essential fatty acids and immune response.FASEB J. 1989; 3: 2052-2061
- Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation.Science. 1983; 220: 568-575
- Prostaglandins and leukotrienes as inflammatory mediators.Br Med Bull. 1987; 43: 285-296
- Prostaglandins, leukotrienes and the immune response.in: Cambridge University Press, 1988: 3
- The leukotrienes in allergy and inflammation.Science. 1982; 215: 1380-1383
- The evolution of non-steroidal anti-inflammatory drugs and their mechanism of action.Drugs. 1987; 33: 18-27
- Leukotrienes: their formation and role as inflammatory mediators.in: Fed Proc. 44. 1985: 25-29
- In vitro inhibition and stimulation of purified prostaglandin endoperoxide synthase by flavonoids: structure-activity relationship.Pharmacology. 1992; 44: 1-12
- Mechanism of inactivation of lipoxygenases by phenidone and BW755C.Biochemistry. 1991; 30: 8964-8970
- Effects of nonsteroidal anti-inflammatory drugs on endogenous gastrointestinal prostaglandins and therapeutic strategies for prevention and treatment of nonsteroidal anti-inflammatory drug-induced damage.Arch Intern Med. 1992; 152: 1145-1155
- A new approach to anti-inflammatory drugs.Biochem Pharmacol. 1979; 28: 1959-1961
- In vitro inhibition of mouse epidermal cell lipoxygenase by flavonoids: structure-activity relationships.Carcinogenesis. 1986; 7: 33-36
- Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis.Experientia. 1988; 44: 230-232
- Mechanisms involved in the anti-inflammatory effect of propolis extract.Drug Exp Clin Res. 1993; 19: 197-203
- Antibacterial, antifungal, antiamoebic, anti-inflammatory and antipyretic studies on propolis bee products.J Ethnopharmacol. 1991; 35: 77-82
- Antibacterial properties of propolis (bee glue).J Roy Soc Med. 1990; 83: 159-160
- Propolis allergy (I). Origin, properties, usage and literature review.Contact Dermatitis. 1987; 17: 163-170
- Propolis allergy. (III). Sensitization studies with minor constituents.Contact Dermatitis. 1988; 19: 296-303
- Propolis: a review.Bee World. 1979; 60: 59-84
- Qualitative and quantitative analysis of flavonoids and identification of phenolic acids from a propolis extract.J Pharm Belg. 1995; 50: 438-444
- Effects of flavonoids on immune and inflammatory cell functions.Biochem Pharmacol. 1992; 43: 1167-1179
- Redox intermediates of flavonoids and caffeic acid esters from propolis: an EPR spectroscopy and cyclic voltammetry study.Free Rad Biol Med. 1995; 18: 901-908
- Carcinogenicity, mutagenicity and cancer preventing activities of flavanoids: A structure-system-activity relationship (SSAR) analysis.Prog Drug Res. 1994; 42: 133-166
- Potential drugs from propolis.in: Frigerio A Ghisalberti E.L Mass Spectrometry in Drug Metabolism. Plenum Press, New York1977: 111
- The analysis of bud exudate of Populus x euramericana, and of propolis, by gas chromatography-mass spectrometry.in: Proc Roy Soc Lon. B232. 1987: 249-272
- Immunomodulatory action of propolis. V. Anticomplementary activity of a water-soluble derivative.J Ethnopharmacol. 1995; 47: 135-143
- Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon.Cancer Res. 1993; 53: 4182-4188
- Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells.Cancer Res. 1995; 55: 3576-3583
- Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties.FEBS Lett. 1993; 329: 21-24
- Lipophilic derivatives of caffeic acid as lipoxygenase inhibitors with antioxidant properties.Bioorg Khim. 1995; 21: 143-151
- Effects of dietary lipid manipulation upon inflammatory mediator production by murine macrophages.Cell Immunol. 1995; 163: 120-128
- Essential fatty acid deficiency inhibits the in vivo generation of leukotriene B4 and suppresses levels of resident and elicited leukocytes in acute inflammation.J Immunol. 1988; 140: 228-233
- Enzyme immunoassays of eicosanoids using acetylcholinesterase.Method Enzymol. 1990; 187: 82-89
- Secretory products of macrophages and their physiological functions.Am J Physiol. 1984; 246: C1-C9
- The role of phagocytic cells in host defense and inflammatory disease.Nutrition. 1990; 6: 5-15
- Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage.J Clin Ivest. 1987; 80: 1114-1124
- Modification of platelet function and arachidonic acid metabolism by bioflavonoids.Biochem Pharmacol. 1984; 33: 1525-1530
- In vivo suppression of prostaglandins biosynthesis by nonsteroidal antiinflammatory agents.Prostaglandins. 1976; 12: 1037-1051
- Hemodynamic effects of indomethacin in chronically instrumented pregnant sheep.Am J Obstet Gynecol. 1985; 151: 484-494
- Immunomodulatory action of propolis. VI. Infuence of a water soluble derivative on complement activity in vivo.J Ethnopharmacol. 1995; 47: 145-147
Article info
Publication history
Accepted:
May 16,
1996
Received:
May 1,
1996
Identification
Copyright
© 1996 Published by Elsevier Inc.
