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Research Article| Volume 59, ISSUE 3, P169-174, September 1998

Preservation of myocardial metabolism in acute coronary artery occlusions with retrograde coronary sinus perfusion and iloprost

DOI:https://doi.org/10.1016/S0952-3278(98)90058-8
Preservation of myocardial metabolism in acute coronary artery occlusions with retrograde coronary sinus perfusion and iloprost
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      Abstract

      A total of 12 healthy mongrel dogs were subjected to the study. The left anterior descending artery was occluded. The occlusion was done for 15 min. At the end of this period, without removing the occlusion, the heart was retroperfused for 3 h. Then, occlusion was removed and reperfusion was supplied. Animals were divided into two equal groups. Six animals received iloprost and the other six control did not receive any additional treatment. In the iloprost group, the drug was administered into the coronary sinus.
      After 15 min following occlusion, iloprost was infused at a rate of 50 μg/min continuously. Cardiac output (CO), mean arterial pressure (MAP), mean pulmonary arterial pressure (MPAP), heart rate (HR), pulmonary capillary wedge pressure (PCWP), right atrium pressure (RAP), myocardial oxygen extraction (MOE) and myocardial lactate extraction (MLE) parameters were examined in the two groups, before and during retroperfusion and during the reperfusion (1–4 h). Iloprost retroperfusion (50 μg/min) was started at the fifteenth minute of occlusion and continued till the end of the observation period (3 h).
      The measured hemodynamic data showed that the hearts treated with iloprost had satisfactory preservation of cardiac function. At the end of the reperfusion period cardiac output was 1.5 ± 0.06 L/min in the control and 1.7 ± 0.04 L/min in the iloprost group (P < 0.05). At the end of the reperfusion period, tumor necrosis factor level was raised significantly in the control group (P < 0.05). Myocardial lactate release was also high in the control group (P < 0.05). CPK-MB release was low in the iloprost group (P < 0.05).
      We conclude that retrogradely administered iloprost reduced the risk of myocardial injury and it is probable that this drug effectively distributes to the area of myocardium at risk.
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      References

        • Katircioğlu S.F
        • Küçükaksu D.S
        • Bozdayi M
        • et al.
        Beneficial effects of prostacyclin treatment on reperfusion of the myocardium.
        Cardiovasc Surg. 1995; 4: 405
        • Katircioğlu S.F
        • Küçükaksu D.S
        • Küplülü S
        • et al.
        Effects of prostacyclin on spinal cord ischemia: An experimental study.
        Surgery. 1993; 114: 36
        • Katircioğlu S.F
        • Saritaş Z
        • Yücel D
        • Bayazit M
        • Taşdemir O
        • Bayazit K
        Spinal cord protection with the use of prostacyclin during aortic occlusion.
        Journal of Surgical Research. 1996; 65: 77-81
        • Katircioğlu S.F
        • Saritaş Z
        • Küçüker S
        • Taşdemir O
        • Bayazit K
        Enoximone usage for experimental spinal cord protection during aortic cross-clamping.
        Thorac Cardiovasc Surgeon. 1996; 44: 245
        • Katircioğlu S.F
        • Küçükaksu D.S
        • Bozdayi M
        • et al.
        Effects of prostacyclin on heparin reversal with protamine.
        Vasc Surgy. 1992; 26: 464
        • Katircioğlu S.F
        • Gökçe P
        • Özgencil E
        • et al.
        Prostacyclin usage for spinal cord protection during experimental thoracic aortic cross clamping.
        Vasc Surg. 1996; 30: 97
        • Wasowicz W
        • Neve J
        • Peretz A
        Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: Importance of extraction pH and influence of sample preservation and storage.
        Clin Chem. 1993; 39: 2522-2526
        • Wayner D.D.M
        • Burton G.W
        • Ingold K.U
        • Barclay L.R.C
        • Locke S.J
        The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma.
        Biochim Biophys Acta. 1987; 924: 408-419
        • Opie L.H
        The mechanism of myocyte death in ischaemia.
        European Heart J. 1993; 14: 31-33
        • Katircioğlu S.F
        • Küçükaksu D.S
        • Gökçe P
        • Özgencil E
        • Tasdemir O
        • Bayazit K
        Coronary sinüs retroperfusion combined with intraaortic balloon pumping to perfuse the acutely ischemic myocardium.
        Thorac Cardiovasc Surgeon. 1994; 42: 330-332
        • Farcot J.C
        • Berdeaux A
        • Giudicelli J.F
        • Vilaine J.P
        • Bourdarias J.P
        Diastolic synchronized retroperfusion versus reperfusion: Effects on regional left ventricular function and myocardial blood flow during acute coronary occlusion in dogs.
        The American Journal of Cardiology. 1983; 51: 1414-1421
        • Farcot F.C
        • Meerbaum S
        • Lang T
        • Kaplan L
        • Corday E
        Synchronized retroperfusion of coronary veins for circulatory support of jeopardized ischemic myocardium.
        The American Journal of Cardiology. 1978; 41: 1191-1201
        • Markov A.K
        • Lehan P.H
        • Hellems H.K
        Reversal of acute myocardial ischemia in closed chest animals by retrograde perfusion of coronary sinüs with arterial blood.
        Acta Cardiol. 1976; 31: 185-199
        • Mohl W
        The relevance of coronary sinüs interventions in cardiac surgery.
        Thorac Cardivasc Surgeon. 1991; 39: 245-250
        • Smith G.T
        • Geary G.G
        • Blanchard W
        • McNamara J.J
        Reduction in infarct size by syncronized coronary venous retroperfusion of arterialized blood.
        The American Journal of Cardiology. 1981; 48: 1064-1070
        • Smith J.V
        Molecular determinations of neutrophil adhesion.
        Am J Respir Cell Mol Biol. 1990; 2: 487-489
        • Tonneson M.G
        Neutrophil-endothelial cell interaction: Mechanisms of neutrophil adherence to vascular endothelium.
        J Invest Dermatol. 1989; 93: 53S-58S
        • Bevilaacqua M.P
        • Pober J.S
        • Mendrick D.L
        • et al.
        Identification of an inducible endothelial-leukocyte adhesion molecule.
        in: Proc Natl Acad Sci USA. 84. 1987: 9238-9242
        • Aiken J.W
        • Gorman R.R
        • Shebuski R.J
        Prevention of blockage of partially obstructed coronary arteries with prostacyclin correlates with inhibition of platelet aggregation.
        Prostaglandins. 1979; 17: 483-494
        • Judgett B.F
        • Hutchins G.M
        • Bulkley B.H
        • Becker L.C
        Infarct size reduction by prostacyclin after coronary occlusion in conscious dogs.
        Clin Res. 1979; 27: 177A
        • Lefer A.M
        • Ogletree M.N.L
        • Smith J.B
        • Silver M.J
        • Nicolaou K.C
        • Barnette W.E
        • Gasic G.P
        Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischaemia.
        Science. 1978; 200: 52-54
        • Fantone J
        • Kinnes D.A
        Prostaglandin E1 and prostaglandin I2 modulation of superoxide production by human neutrophils.
        Biochem Biophys Res Commun. 1983; 113: 506-512
        • Schoror K
        • Ohlendorf R
        • Darius H
        Beneficial effects of a new carbacyclin derivative, ZK 36374 in acute myocardial ischemia.
        J Pharmacol Exp Ther. 1981; 219: 243-249
        • Van der Giessen W.J
        • Schoutsen B
        • Tijssen J.G.P
        • Verdouw P.D
        Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig.
        Br J Pharmacol. 1986; 87: 23-27
        • Pohlman T.H
        • Stanness K.A
        • Beatty P.G
        • et al.
        An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor α increases neutrophil adherence by a CDw 18-dependent mechanism.
        J Immunol. 1986; 136: 4548-4553
        • Tsujimoto M
        • Yokota S
        • Vilcek J
        • et al.
        Tumor necrosis factor provokes superoxide anion generation from neutrophils.
        Biochem Biophys Res Commun. 1986; 137: 1094-1098
        • Bevilacqua M.P
        • Wheeler M.E
        • Pober J.S
        • et al.
        Endothelial-dependent mechanisms of leukocyte adhesion: regulation by interleukin-1 and tumor necrosis factor.
        in: Movat H.Z Leukocyte Emigration and Its Sequelae. Karger, New York1979: 179
        • Meyer J.D
        • Yurt R.W
        • Duhaney R
        • et al.
        Tumor necrosis factor-echanbed leukotriene B4 generation and chemotaxis in human neutrophils.
        Arch Surg. 1988; 123: 1454-1458
        • Shalby M.R
        • Aggarwal B.B
        • Rinderknecht E
        • et al.
        Activation of human polymorphonuclear neutrophil function by interferongamma and tumor necrosis factor.
        J Immunol. 1985; 135: 2069

      Article info

      Publication history

      Accepted: July 2, 1998
      Received: April 14, 1998

      Identification

      DOI: https://doi.org/10.1016/S0952-3278(98)90058-8

      Copyright

      © 1998 Published by Elsevier Inc.

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