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In immature female rats (21 days), a restricted diet (50% of the daily normal intake for 25 days) interrupts sexual development, leaving animals in a state of sexual immaturity. Food restriction does not affect the use of glycogen in uteri isolated and increases 14CO2 production from U14C-glucose in relation to animals receiving normal feeding that reach sexual maturity. Indomethacin and acetylsalicylic acid stop the increase of glucose metabolism produced by underfeeding, without affecting the uteri of rats receiving normal feeding. The addition of PGE2 and PGF2α changes the inhibitory effect of indomethacin. Nordihydroguaiaretic acid produces the opposite effect, increasing glucose metabolism only in uteri isolated from immature animals. These results show that immature animals have a higher glucose metabolism if compared to mature rats. The restricted diet, which slows down sexual maturity, keeps this parameter high due to the influence of some eicosanoids.
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Accepted: July 2, 1998
Received: February 12, 1998
© 1998 Published by Elsevier Inc.