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Abstract
We examined effects of a thromboxane A2 (TXA2) antagonist seratrodast on airway hyperresponsiveness, exhaled nitric oxide (NO),
and eosinophils in induced sputum in 14 asthmatics. Subjects were administered 80
mg of seratrodast once a day for 4 weeks. Respiratory conductance (Grs) was measured
by the forced oscillation method and airway responsiveness was evaluated as the inhaled
dose of methacholine, which induced 35% decrease in Grs. Subjects breathed into a
Teflon bag, and NO concentration in the bag was measured by a chemiluminescence analyzer.
Induced sputum comprised the entire expectorate produced during a 20 min inhalation
of 3% saline, and was analyzed for total and differential cell counts. Airway hyperresponsiveness
was significantly decreased by seratrodast. By contrast, no differences in either
exhaled NO or percentage of eosinophils in sputum were observed before or after seratrodast.
We conclude that seratrodast may attenuate airway hyperresponsiveness, presumably
by antagonizing TXA2 released from the inflamed airways.
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Article info
Publication history
Accepted:
July 17,
1998
Received:
March 13,
1998
Identification
Copyright
© 1998 Published by Elsevier Inc.
