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Abstract
Insulin resistance is an important condition which underlies much of the coronary
artery disease in affluent societies. We have related insulin resistance, as assessed
by fasting plasma insulin, to erythrocyte membrane composition in 54 healthy men and
women on a low fat diet. We found a inverse relationship (r = −0.41, P = 0.002) between fasting plasma insulin and the percentage of arachidonic acid in
erythrocyte fatty acids. An inverse relationship of similar strength was found with
total n-6 fatty acids and a positive relationship was found with the percentage of
saturated fatty acids (r = 0.39, P < 0.01). No relationship was found with n-3 fatty acids. We would suggest that n-6
fatty acids, and in particular arachidonic acid, modify the membrane environment of
the insulin receptor (or the glucose transporters) so that lower levels of insulin
are required for glucose homeostasis.
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Article info
Publication history
Accepted:
July 17,
1998
Received:
June 22,
1998
Identification
Copyright
© 1998 Published by Elsevier Inc.
