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Abstract
We investigated effects of lipo-pro-prostaglandin E1 (lipo-[11α, 13E, 15S]-11,15-dihydroxy-9-[1-oxobutoxy]-prosta-8, 13-dien-1-oic acid
butyl ester), AS-013 in two models of hearing disturbance and equilibrium dysfunction
induced by rat inner ear microcirculatory thrombosis. Inner ear microcirculatory thrombosis
was induced by photochemical reaction between systemic injection of Rose Bengal and
irradiation of green light to the cochlea and vestibule. Photochemical reaction causes
endothelial injury followed by platelet adhesion, aggregation and formation of a platelet-
and fibrin-rich thrombus. In the hearing disturbance model, a compound cochlear nerve
action potential was recorded by electrocochleography every minute. Photochemical
reaction induced inner ear microcirculatory thrombosis, followed by disappearance
of the action potential. AS-013 significantly (P<0.05) prolonged time to disappearance of the action potential compared with control
group. In the equilibrium dysfunction model, the irradiation to the vestibule was
applied for 10 min after Rose Bengal injection. The behavior of rats in the swimming
test and nystagmus were observed 24 h after the completion of irradiation. In the
swimming test, two of 12 animals treated with AS-013 showed no rotating about their
longitudinal axes, which indicates equilibrium dysfunction and the duration of well-balanced
swimming prolonged. AS-013 suppressed the appearance of nystagmus. These results suggest
that lipo-pro-prostaglandin E1, AS-013 may prevent hearing disturbance and equilibrium dysfunction due to inner
ear microcirculatory disorders.
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Article info
Publication history
Accepted:
July 17,
1998
Received:
June 16,
1998
Identification
Copyright
© 1998 Published by Elsevier Inc.
