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Abstract
Supplementation with essential fatty acids has been shown to prevent the experimentally
induced ectopic calcification of the kidneys known as nephrocalcinosis. Male Sprague-Dawley
rats were fed a semi-synthetic diet supplemented with different essential fatty acids
while being injected for a period of 10 days with calcium glubionate. After 3 weeks
their kidneys and aorta were removed and the respective calcium content measured compared
to the control, saline injected animals. Lipoic acid-EPA, fish oil (EPA rich) as well
as the EPA monoester reduced the calcium concentration of both the kidneys and the
aorta towards control values. Lipoic-EPA was the best absorbed of the three compounds
and its combination of anti-oxidant together with EPA lowered the calcium content
of both the aortas and the kidneys.
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Article info
Publication history
Accepted:
July 17,
1998
Received:
May 16,
1998
Identification
Copyright
© 1998 Published by Elsevier Inc.
